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Research Projects

The projects below are part of the research line UMCN 1-2 of the UMCN: Chromosomal aberrations, and cancer. Please click on the project of choice to display the corresponding information.

Breakage-prone sites in human chromosomes
Cancer predisposition: identification of novel genes using patients with constitutional chromosome aberrations and malformation syndromes
Epigenetic gene (de)regulation mediated by the synovial sarcoma-associated SS18 and SSX (fusion) proteins
Identification and characterization of novel prognostic and therapeutic targets in childhood acute lymphoblastic leukemia
Identification of novel colorectal cancer predisposing genes using (ultra) high resolution genomic profiling
Also involved in:
Detection of chromosomal aberrations in childhood ALL at diagnosis and at minimal residual disease by array CGH
Genetic defects in relapsed acute lymphoblastic leukemia
BTG1, a mediator of therapy resistance in pediatric acute lymphoblastic leukemia
Role of Ikaros family of transcription factors in the outgrowth and therapy resistance of pediatric acute lymphoblastic leukemia

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