Below you will find a list of key publications by the Tumour Cell Genetics Research group.

Latest Pubmed publication list

M.J. Ligtenberg, R.P Kuiper, T.L. Chan, M. Goossenes, K.M. Hebeda, M. Voorendt, T.Y.H. Lee, D. Bodmer, E. Hoenselaar, H.G. Brunner, A. Geurts van Kessel, S.T. Yuen, J.H.J.M. van Krieken, S.Y. Leung and N. Hoogerbrugge. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3’ exons of TACSTD1. Nature Genet. 41: 112-117 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19098912?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

S. Langemeijer, R.P. Kuiper, M. Berends, R. Knops, M.G. Aslanyan, M. Massop, E. Stevens-Linders, P. van Hoogen, A. Geurts van Kessel, R.A.P. Raymakers, E..J. Kamping, G.E. Verhoef, E. Verburgh, A. Hagemeijer, P. Vandenberghe, T. de Witte, B.A. van der Reijden and J.H. Jansen. Acquired mutations in TET2 are common in myelodysplatic syndromes. Nature Genet. 41: 838-842 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19483684?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

K. Medendorp, J.J.M. van Groningen, L. Vreede, L. Hetterschijt, L. Brugmans, W.H. van den Hurk and A. Geurts van Kessel. The renal cell carcinoma associated oncogenic protein PRCCTFE3 provokes p21WAF1/CIP1-mediated cell cycle arrest. Exp. Cell Res. 315: 2399-2409 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19422821?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

L.E.L.M. Vissers, S.S. Bhatt, I.M. Janssen, Z. Xia, R.Pfundt, K. Derwinska, B.B.A. de Vries, C.Gilissen, A. Hoischen, M. Nesteruk, B. Wisniowiecka-Kowalnik, M. Smyk, H.G. Brunner, S.W. Cheung, A. Geurts van Kessel, J.A. Veltman, P. Stankiewicz. Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture. Hum. Mol. Genet. 18: 3579-3593 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19578123?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

R.P. Kuiper, L. Vreede, C. Ricketts, R. Venkatachalam, F. van Erp, N. Hoogerbrugge, L. van Kempen, E. Schoenmakers, A. Bonne, E. Maher and A. Geurts van Kessel. The tumor suppressor gene FBXW7 is disrupted by a constitutional t(2;3)(q22;q31) in a patient with renal cell cancer Cancer Genet. Cytogenet. (2009, in press).

M.C.J. Jongmans, R.P. Kuiper, C. L. Carmichael, E. J. Wilkins, N. Dors, A. Carmagnac, A.Y.N. Schouten-van Meeteren, X. Li, E. Kamping, H. Bengtsson, E.F.P.M. Schoenmakers, A. Geurts van Kessel, P.M. Hoogerbrugge, C.N. Hahn, P.P. Brons, H.S. Scott and N. Hoogerbrugge. Novel RUNX1 mutations in familial platelet disorder with enhanced risk for AML: clues for improved identification of the FPD/AML syndrome. Leukemia (2009, in press).

C.Graux, M. Stevens-Kroef, M. Lafage, N. Dastugue, K. Bahloula, F. Mugneret, S. Struski, M.J. Grégoire, N. Nadal, E. Lippert, P. Vandenberghe, S. Taviaux, A. Simons, R.P. Kuiper, L. Michaux, A. Bosly, I. Lahortiga, K. De Keersmaecke, I. Wlodarska, J. Cools, A. Hagemeijer and H.A. Poire. Heterogeneous pattern of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. Leukemia 23:125-133 (2009).

M.V. Yusenko, R.P. Kuiper, T. Boethe, B. Ljungberg, A. Geurts van Kessel and G. Kovacs. High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer 9: 152 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19445733?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

K. Medendorp, J.J.M. van Groningen, L. Vreede, L. Hetterschijt, W.H. van den Hurk, D. de Bruijn and A. Geurts van Kessel. The mitotic arrest deficient protein Mad2B interacts with the small GTPase RAN throughout the cell cycle. PLoSONE 4: e7020 (2009). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19753112?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

D. de Bruijn, M. Willemse, A. van Dijk and A. Geurts van Kessel. The C-terminus of the synovial sarcoma associated SSX proteins interacts with the LIM domain homeobox protein LHX4. Oncogene 27: 653-662 (2008). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/17667940?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

R. Venkatachalam, M.J.L. Ligtenberg, N. Hoogerbrugge, A. Geurts van Kessel and R.P. Kuiper. Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanisms. Genome Res. 123:188-194 (2008). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/19287155?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5

J.M. Lubieniecka, D.R.H. de Bruijn, A.H.A. van Dijk, S. Subramanian, M. van de Rijn, N. Poulin, A. Geurts van Kessel and T.O. Nielsen. Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma. Cancer Res. 68: 4303-4310 (2008). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/18519690?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=13

D. R.H. de Bruijn, J.P Nap and A. Geurts van Kessel. The (epi)genetics of human synovial sarcoma. Genes Chrom. Cancer 46: 107-117 (2007). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/17117414?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

R.P Kuiper, E. Schoenmakers, S. van Reijmersdal, J. Hehir, R. Pieters, A. Geurts van Kessel, F.N. van Leeuwen and P.M. Hoogerbrugge. High resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 21: 1258-1266 (2007). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/17443227?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11

D. de Bruijn, W. Peters, S. Chuva de Sousa Lopes, A. van Dijk, M. Willemse, R. Pfundt, P de Boer and A. Geurts van Kessel. Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. 15: 2936-2944 (2006). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/16926188?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

L. Looijenga, R. Hersmus, A. Gillis, H. Stoop, R. van Gurp, J. Veltman, B. Beverloo, A. Geurts van Kessel, N. Galjart, D. Zarkower, R. Reijo Pera, D. Schneider, P. van der Spek, E. Schoenmakers and J.W. Oosterhuis. Genomic and expression profiling of human spermatocytic seminomas; primary spermatocyte as tumorigenic precursor cell and DMRT1 as candidate chromosome 9 gene. Cancer Res. 66: 290-302 (2006). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/16397242?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4

D. de Bruijn, S. Allander, A. van Dijk, M. Willemse, P. Meltzer and A. Geurts van Kessel. The synovial sarcoma-associated SS18-SSX2 fusion protein induces epigentic gene (de)regulation. Cancer Res. 66: 9474-9482 (2006). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/17018603?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

M. Stevens-Kroef, E. Schoenmakers, M. van Kraaij, E. Huys, S. Vermeulen, B. van der Reijden and A. Geurts van Kessel. Identification of truncated RUNX1 as well as RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive AML. Leukemia 20: 1187-1189 (2006).

D. Koolen, L. Vissers, R. Pfundt, N. de Leeuw, S. Knight, R. Regan, F. Kooy, E. Reyniers, C. Romano, M. Fichera, A. Schinzel, A. Baumer, B. Anderlid, J. Schoumans, N. Knoers, A. Geurts van Kessel, E. Sistermans, J. Veltman, H. Brunner and B. de Vries. A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism. Nature Genet. 38: 999-1001 (2006). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/16906164?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8

de Bruijn DR, Geurts van Kessel A. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. Cytogenet Genome Res. 112(3-4):222-6 (2006). Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484776

I.M. Veltman, L.A. Vreede, B. Janssen, J. Cheng, E. Yeh, L.H.J. Looijenga, E.F.P.M. Schoenmakers and A. Geurts van Kessel. Fusion of the SUMO-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESD in a patient with a neonatal teratoma and a constitutional t(12;15;q13;q25). Hum. Mol. Genet. 14: 1955-1963 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15917269?dopt=Abstract

I.M. Veltman, J.A. Veltman, I.M. Janssen, C.A. Hulsbergen-van de Kaa, W. Oosterhuis, D.T. Schneider, H. Stoop, A Gillis, S. Zahn, L.H.J. Looijenga, U. Gobel and A. Geurts van Kessel. Identification of recurrent chromosomal aberrations in germ cell tumors of neonates and infants using genome-wide array-based comparative genomic hybridization. Chrom. Cancer 43: 367-376 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15880464?dopt=Abstract

R. Pfundt, F. Smit, C. Jansen, T. Aalders, H. Straatman,W. van der Vliet, J. Isaacs, A. Geurts van Kessel and J. Schalken. Identification of androgen responsive genes that are alternatively regulated in androgen dependent and androgen independent rat prostate tumors. Chrom. Cancer 43: 273-283 (2005). Pubmed-link: "http://www.ncbi.nlm.nih.gov/pubmed/15834941?dopt=Abstract

M. Heidenblad, D. Lindgren, E.F.P.M. Schoenmakers, E.H. Mahlamaki, T. Jonson, L. Gorunova, A. Geurts van Kessel, J. Veltman and M. Hoglund. Microarray analyses reveal strong influence of copy number alterations on the transcriptional patterns in pancreatic cancer; implications for the interpretation of genomic amplifications. Oncogene 24: 1794-1801 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15688027?dopt=Abstract

M. Schraders, R Pfundt, H.M.P. Straatman, I.M. Janssen, A. Geurts van Kessel, E.F.P.M. Schoenmakers, J.H.J.M. van Krieken and P.J.T.A. Groenen. Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization. Blood 105: 1686-1693 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15498857?dopt=Abstract

Taylor BJ, Reiman T, Pittman JA, Keats JJ, de Bruijn DR, Mant MJ, Belch AR, Pilarski LM. SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs. J Immunother. 28(6):564-75 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16224274

Vissers LE, Veltman JA, Geurts van Kessel A, Brunner HG. Identification of disease genes by whole genome CGH arrays. Human Molecular Genetics, 15;14 Spec No. 2:R215-23 (2005). Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16244320

B.B. de Vries, R. Pfundt, M. Leisink, D.A. Koolen, L.E.L.M. Vissers, I.M. Janssen, S. Reijmersdal, W.M. Nillesen, E.H.L.P.G. Huys, N. de Leeuw, D. Smeets, E.A. Sistermans, T. Feuth, C.M.A. van Ravenswaaij-Arts, A. Geurts van Kessel, E.F.P.M. Schoenmakers, H.G. Brunner and J.A. Veltman. Diagnostic genome profiling in mental retardation. Am J Hum Genet. 77: 606-616 (2005) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16175506&dopt=Abstract

I.M. Veltman, L.A. Vreede, B. Janssen, J. Cheng, E. Yeh, L.H.J. Looijenga, E.F.P.M. Schoenmakers and A. Geurts van Kessel. Fusion of the SUMO-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESD in a patient with a neonatal teratoma and a constitutional t(12;15;q13;q25). Hum. Mol. Genet. 14: 1955-1963 Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15917269&dopt=Abstract

I.M. Veltman, J.A. Veltman, I.M. Janssen, C.A. Hulsbergen-van de Kaa, W. Oosterhuis, D.T. Schneider, H. Stoop, A Gillis, S. Zahn, L.H.J. Looijenga, U. Gobel and A. Geurts van Kessel. Identification of recurrent chromosomal aberrations in germ cell tumors of neonates and infants using genome-wide array-based comparative genomic hybridization. Genes Chrom. Cancer 43: 367-376 (2005) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15880464&dopt=Abstract

R. Pfundt, F. Smit, C. Jansen, T. Aalders, H. Straatman,W. van der Vliet, J. Isaacs, A. Geurts van Kessel and J. Schalken. Identification of androgen responsive genes that are alternatively regulated in androgen dependent and androgen independent rat prostate tumors. Genes Chrom. Cancer 43: 273-283 (2005) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15834941&dopt=Abstract

M. Heidenblad, D. Lindgren, E.F.P.M. Schoenmakers, E.H. Mahlamaki, T. Jonson, L. Gorunova, A. Geurts van Kessel, J. Veltman and M. Hoglund. Microarray analyses reveal strong influence of copy number alterations on the transcriptional patterns in pancreatic cancer; implications for the interpretation of genomic amplifications. Oncogene 24: 1794-1801 (2005) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15688027&dopt=Abstract

M. Schraders, R Pfundt, H.M.P. Straatman, I.M. Janssen, A. Geurts van Kessel, E.F.P.M. Schoenmakers, J.H.J.M. van Krieken and P.J.T.A. Groenen. Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization. Blood 105: 1686-1693 (2005) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15498857&dopt=Abstract

R.P. Kuiper, M. Schepens, J. Thijssen, E.F.P..M. Schoenmakers and A. Geurts van Kessel. Degulation of the MITF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains. Nucl. Acids Res. 32: 2315-2332 (2004). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15118077?dopt=Abstract

M. Heidenblad, E.F.P.M. Schoenmakers, T. Jonson, J.A. Veltman, A. Geurts van Kessel and M. Hoglund. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinomas. Cancer Res. 64: 3052-3059 (2004). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/15126341?dopt=Abstract

L.E.L.M. Vissers, C.M.A. van Ravenswaaij, R. Admiraal, J.A. Hurst, B.B.A. de Vries, I.M. Janssen, W.A. ven der Vliet, E.H.L.P.G. Huys, P.J. de Jong, B.C.J. Hamel, E.F.P.M Schoenmakers, H.G. Brunner, J.A. Veltman and A. Geurts van Kessel. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nature Genet. 36: 955-957 (2004) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15300250&dopt=Abstract

J.A. Veltman, H.G. Yntema, D. Lugtenberg, H. Arts, S. Briault, E.L.P.G. Huys, K. Osoegawa, P. de Jong, H.G. Brunner, A. Geurts van Kessel, H. van Bokhoven and E.F.P.M. Schoenmakers High resolution profiling of X chromosomal aberrations by BAC array. J. Med. Genet. 41: 425-432 (2004) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15173227&dopt=Abstract

R.P. Kuiper, M. Schepens, J. Thijssen, E.F.P..M. Schoenmakers and A. Geurts van Kessel. Regulation of the MITF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains. Nucl. Acids Res. 32: 2315-2332 (2004) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15118077&dopt=Abstract

M. Heidenblad, E.F.P.M. Schoenmakers, T. Jonson, J.A. Veltman, A. Geurts van Kessel and M. Hoglund. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinomas. Cancer Res. 64: 3052-3059 (2004) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15126341&dopt=Abstract

L.E.L.M. Vissers, B.B.A. de Vries, K. Osoegawa, I.M. Janssen, T. Feuth, C.O. Choy, H. Straatman, W. van der Vliet, E.H.L.P.G. Huys, A. van Rijk, D. Smeets, C.M.A. van Ravenswaaij-Arts, N. Knoers, I. Van der Burgt, P.J. de Jong, H.G. Brunner, A. Geurts van Kessel, E.F.P.M. Schoenmakers and J.A. Veltman. Array-based comparative genomic hybridisation for genome wide detection of submicroscopic chromosome abnormalities Am. J. Hum. Genet. 73: 1261-1270 (2003) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14628292&dopt=Abstract

R.P. Kuiper, M. Schepens, J. Thijssen, M. van Asseldonk, E. van den Berg, J. Bridge, E. Schuuring, E. Schoenmakers and A. Geurts van Kessel. Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter sustitution. Hum. Mol. Genet. 12: 1661-1669 (2003). Pubmed-link: http://www.ncbi.nlm.nih.gov/pubmed/12837690?dopt=Abstract

I.M. Veltman, J.A. Veltman, G. Arkesteijn, I.M. Janssen, L.E. Vissers, P.J. de Jong, A. Geurts van Kessel and E.F.P.M. Schoenmakers Chromosomal breakpoint mapping by array CGH using flow sorted chromosomes BioTechniques 35: 1066-1070 (2003) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14628681&dopt=Abstract

R.P. Kuiper, M. Schepens, J. Thijssen, M. van Asseldonk, E. van den Berg, J. Bridge, E. Schuuring, E. Schoenmakers and A. Geurts van Kessel. Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter sustitution Hum. Mol. Genet. 12: 1661-1669 (2003) Pubmed-link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12837690&dopt=Abstract